No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder.
(2000) European Journal of Human Genetics — Vol. 8, n° 5, p. 385-388 (2000)
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- Authors
Tissir, Fadel 
- Abstract
- We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.
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Citations
Goossens, D., Villafuerte, S., Tissir, F., Van Gestel, S., Claes, S., Souery, D., Massat, I., Van den Bossche, D., Van Zand, K., Mendlewicz, J., Van Broeckhoven, C., & Del-Favero, J. (2000). No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder. European Journal of Human Genetics, 8(5), 385-388. https://doi.org/10.1038/sj.ejhg.5200469 (Original work published 2000)