Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

Crosignani, Stefano;Bingham, Patrick;Bottemanne, Pauline;Cannelle, Hélène;Wythes, Martin;et.al.
(2017) Journal of Medicinal Chemistry — Vol. 60, p. 9617-9629 (2017)

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Crosignani, S., Bingham, P., Bottemanne, P., Cannelle, H., Cauwenberghs, S., Cordonnier, M., Dalvie, D., Deroose, F., Feng, J. L., Gomes, B., Greasley, S., Kaiser, S. E., Kraus, M., Négrerie, M., Maegley, K., Miller, N., Murray, B. W., Schneider, M., Soloweij, J., et al. (2017). Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. Journal of Medicinal Chemistry, 60, 9617-9629. https://doi.org/10.1021/acs.jmedchem.7b00974 (Original work published 2017)