Anti-inflammatory compounds from leaves and root bark of Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg.
(2008) Journal of Ethnopharmacology — Vol. 115, n° 1, p. 25-29 (2008)
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- Abstract
- Alchornea cordifolia is one of the most widely-used plants in traditional medicine throughout Africa, principally for inflammatory, antimicrobial and parasitic diseases. In continuation of our investigations on its anti-inflammatory activity, we fractionated the leaf and root bark extracts and isolated six compounds which exhibited significant topical anti-inflammatory activity in the mouse ear oedema model using croton oil at a dose of 90 microg/cm2. Daucosterol (2), acetyl aleuritolic acid (4), N1,N2-diisopentenyl guanidine (5) and N1,N2,N3-triisopentenyl guanidine (6) were shown to be more active than indomethacin, while beta-sitosterol (1) and di(2-ethylhexyl) phthalate (3) were less effective. This is the first report on the presence of compounds 1, 2, 3 and 4 in this plant and of the anti-inflammatory activity of 3, 5 and 6. These compounds may account, at least in part, for the use of A. cordifolia in folk medicine to treat inflammation.
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Mavar-Manga, H., Haddad, M., Pieters, L., Baccelli, C., Penge, A., & Quetin-Leclercq, J. (2008). Anti-inflammatory compounds from leaves and root bark of Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg. Journal of Ethnopharmacology, 115(1), 25-29. https://doi.org/10.1016/j.jep.2007.08.043 (Original work published 2008)