Récepteur et protéine de liaison de l'hormone de croissance: rôles dans la réceptivité cellulaire à l'hormone de croissance.
(1995) Annales d’endocrinologie — Vol. 56, n° 4, p. 253-258 (1995)
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- Abstract
- In most species, the structure of the growth hormone-binding protein (GH-BP) is identical to that of the growth hormone receptor (GH-R). The affinity (Ka) of the GH-BP is however 10 x lower than that of the receptor. Two mechanisms of production of the GH-BP have been described: in the human and the rabbit, the GH-BP is cleaved near the cellular membrane by proteolysis and shed into the extracellular compartment while in murine species, the serum GH-BP is produced by alternative splicing of the gene coding for the GH receptor. The GH-BP prolongs the 1/2 life of plasma GH, dampening the free GH levels during peaks and maintaining free hormone levels during troughs via the slow dissociation of GH from the complex GH-GHBP. By controlling free GH levels within and between peaks, GH-BP would thus play an important role in modulating GH action at the cellular level. In several physiological and physiopathological conditions, GH-BP and GH-R are coordinately regulated. However, there are situations such as during pregnancy or certain periods of development where these 2 proteins are not co-expressed. Therefore, GH-BP circulating levels do not necessarily represent cellular GH-R concentrations. In the rat, GH-BP and GH-R are regulated by nutritional and endocrine factors, among those are GH, insulin and gonadal steroids. In the human, the mechanism responsible for the increase of the circulating GH-BP during infancy is still unknown. Finally, the eventual role of GH-BP in transmitting the intracellular message of GH following its binding to the receptor is still unknown.
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Maes, M., Maiter, D., Massa, G., & Ketelslegers, J.-M. (1995). Récepteur et protéine de liaison de l’hormone de croissance: rôles dans la réceptivité cellulaire à l’hormone de croissance. Annales d’endocrinologie, 56(4), 253-258. https://hdl.handle.net/2078.5/42459 (Original work published 1995)