Alpha- Or Beta-trifiuoromethyl Epoxysulfones - New C-3 Reagents for Heterocyclization

Laduron, F.;Janousek, Z.;Viehe, HG.
(1995) Journal of Fluorine Chemistry — Vol. 73, n° 1, p. 83-86 (1995)

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Authors
  • Laduron, F.
    Author
  • Janousek, Z.
    Author
  • Viehe, HG.
    Author
Abstract
The syntheses of alpha- and beta-trifluoromethyl epoxysulfones 1 and 2 are described. Compound 1 reacts with nucleophiles and bis-nucleophiles to furnish trifluoromethyl ketones and triRuoromethyl heterocycles in good yield, while its isomer 2 leads to the opposite thiazole regioisomers with thioamides.
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Laduron, F., Janousek, Z., & Viehe, HG. (1995). Alpha- Or Beta-trifiuoromethyl Epoxysulfones - New C-3 Reagents for Heterocyclization. Journal of Fluorine Chemistry, 73(1), 83-86. https://doi.org/10.1016/0022-1139(94)03212-I (Original work published 1995)