Analysis of cis- and trans-acting elements in the hormone-sensitive human somatotropin gene promoter
(1989) Journal of Steroid Biochemistry — Vol. 34, n° 1-6, p. 79-83 (1989)
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- Abstract
- The expression of the human growth hormone (hGH) gene is regulated by several transcription factors. Basal level transcription factors include TATA box-binding proteins, Sp1, USF and CTF/NF-1. The hGH gene is expressed only in pituitary somatotrophs, and the pituitary-specific GHF-1/Pit-1 protein is a potent transcriptional stimulator. Glucocorticoid and thyroid hormones, insulin, and GHRH which acts via cAMP, also control hGH gene transcription via trans-acting factors some of which are the hormone receptors themselves. Three transcription initiation sites were detected when hGH gene promoter activity was studied in a cell-free system. This system enabled us to delineate the respective role of some transcription factors and to propose a model that accounts for the basal, pituitary-specific, and hormonal control of hGH gene expression.
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Lemaigre, F., Courtois, S. J., Durviaux, S. M., Egan, C. J., LaFontaine, D. A., & Rousseau, G. (1989). Analysis of cis- and trans-acting elements in the hormone-sensitive human somatotropin gene promoter. Journal of Steroid Biochemistry, 34(1-6), 79-83. https://doi.org/10.1016/0022-4731(89)90068-X (Original work published 1989)