Part II : aerobic protists - trypanosomatidae
(2003) Molecular Medical Parasitology — ISBN: [978-0-12-473346-6], published
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- This chapter focuses on the carbohydrate metabolism of the Trypanosomatidae, protozoan parasites responsible for a number of important diseases of man. Many enzymes of glycolysis and related pathways in trypanosomatids are sequestered inside microbodies, which makes them usefulnot only as a drug target but also for basic research. The potential for chemotherapeutic exploitation of carbohydrate metabolism is significant. The biochemistry of trypanosomes is studied in great detail, because these organisms harbor many peculiarities that have attracted biochemists interested in fundamental aspects of these organisms. The fact that trypanosomes are among the few parasitic organisms that can easily be grown in large numbers in the blood of infected rodents has facilitated their study. The chapter concludes that the advent of molecular biology where the number of cells available for research is no longer a limiting factor, has led to an enormous growth of the literature over recent years. Through the combined efforts of many researchers in various disciplines over many years, a good understanding of the glycolytic pathway of the African trypanosome is obtained. These efforts have led to the cloning, sequencing, and over expression of all the enzymes of the pathway and the resolution of the crystal structure of many.
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Opperdoes, F. R., & Michels, P. A. (2003). Part II : aerobic protists - trypanosomatidae. In Tim W. Nilsen, Richard W. Komuniecki, James Joseph Marr (ed.), Molecular Medical Parasitology. https://hdl.handle.net/2078.5/219849