Leukemic plasmacytoid dendritic cells share phenotypic and functional features with their normal counterparts.
(2004) European journal of immunology — Vol. 34, n° 2, p. 418-426 (2004)
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- This work aims to further characterize the newly described leukemic plasmacytoid dendritic cells (LPDC), for which we had previously demonstrated their normal, PDC-like ability to produce IFN-alpha. In addition, LPDC also express the specific antigens BDCA-2 and BDCA-4. Importantly, they become fully competent antigen-presenting cells (APC) after a short maturation induced by IL-3 + CD40L or virus, exhibiting a characteristic APC phenotype (high expression of CD83 and of the costimulatory molecules CD40, CD80, CD86). Whereas IL-3 + CD40L-activated LPDC prime naive CD4(+) T cells towards a Th2 pathway (IL-4-secreting T cells), virus-activated LPDC drive a Th1 profile (IFN-gamma-secreting T cells). Moreover, we show in one case that LPDC are able to capture, process and present exogenous antigens, leading to the activation of both CD4(+) and CD8(+) T cell clones in an antigen-specific manner. This study further characterizes the phenotype and immunological functions of LPDC.
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Chaperot, L., Perrot, I., Jacob, M.-C., Blanchard, D., Salaun, V., Deneys, V., Lebecque, S., Brière, F., Bensa, J.-C., & Plumas, J. (2004). Leukemic plasmacytoid dendritic cells share phenotypic and functional features with their normal counterparts. European journal of immunology, 34(2), 418-426. https://doi.org/10.1002/eji.200324531 (Original work published 2004)