Detection and characterization of VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in a clinical isolate of Enterobacter cloacae.
(2012) Antimicrobial Agents and Chemotherapy — Vol. 56, n° 6, p. 3283-3287 (2012)
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- We report the first description of the metallo-β-lactamase VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in Enterobacter cloacae 11236, which was isolated from blood specimens of a patient with colonic adenocarcinoma in Belgium. bla(VIM-31) was found on a class 1 integron located on a self-transferable but not typeable 42-kb plasmid. Compared to values published elsewhere for VIM-2, the purified VIM-31 enzyme showed weaker catalytic efficiency against all the tested beta-lactam agents (except for ertapenem), resulting from lower k(cat) (except for ertapenem) and higher K(m) values for VIM-31
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Bogaerts, P., Bebrone, C., Huang, T.-D., Bouchahrouf, W., De Gheldre, Y., Deplano, A., Hoffmann, K., & Glupczynski, G. (2012). Detection and characterization of VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in a clinical isolate of Enterobacter cloacae. Antimicrobial Agents and Chemotherapy, 56(6), 3283-3287. https://doi.org/10.1128/AAC.06249-11 (Original work published 2012)