Dirithromycin versus amoxiclav in the treatment of acute exacerbations of chronic bronchitis
(1997) The Journal of International Medical Research — Vol. 25, n° 1, p. 33-40 (1997)
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- Abstract
- A total of 334 patients with acute exacerbation of chronic bronchitis were treated with either dirithromycin for 5 days (n = 169) or amoxiclav for 7-10 days (n = 165) in an open randomized trial. The efficacy and tolerability of the two drugs were compared. There was no statistically significant difference in outcome between the two treatment arms. Clinical success (cure or improvement) was obtained in 94.5% and 93.1% of patients treated with dirithromycin and amoxiclav, respectively. Adverse events (mostly gastrointestinal) occurred in both groups, but led to discontinuation of treatment (in only seven patients). We conclude that the two drugs are equally efficacious and safe.
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Citations
VanRoyen, P., Betz, W., Heyrman, J., Taziaux, P., Van den Haute, M., & Poelman, M. (1997). Dirithromycin versus amoxiclav in the treatment of acute exacerbations of chronic bronchitis. The Journal of International Medical Research, 25(1), 33-40. https://hdl.handle.net/2078.5/85901 (Original work published 1997)