Estrogen and insulin modulation of intracellular insulin-like growth factor binding proteins in human breast cancer cells: possible involvement in lysosomal hydrolases oversecretion.

Dubois, Vincent;Couissi, D;Schonne, Edgard;Schneider, Yves-Jacques;Trouet, André;et.al.
(1993) Biochemical and Biophysical Research Communications — Vol. 192, n° 1, p. 295-301 (1993)

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Authors
  • Dubois, VincentUCLouvain
    Author
  • Couissi, D
    Author
  • Schonne, EdgardUCLouvain
    Author
  • Schneider, Yves-JacquesUCLouvain
    Author
  • Remacle, ClaudeUCLouvain
    Author
  • Trouet, AndréUCLouvain
    Author
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Abstract
Differences in insulin-like growth factor binding proteins (IGFBPs) expressed within estrogen receptor positive (ER+, MCF-7/6) and negative (ER-, MDA-MB-231) human breast cancer cells cultured in chemically defined medium were observed. In the absence of insulin, 17 beta-estradiol affects this expression in ER+ cells by significantly reducing 34 and 28 kDa species. In ER+ cells, insulin appears to minimize the estrogen induced reduction of these 34 and 28 kDa IGFBPs and stimulates a 24 kDa type. We suggest that through its association with a given IGFBP, insulin-like growth factor-II (IGF-II) directs lysosomal enzymes to secretion by its binding to the mannose-6-phosphate/IGF-II receptors present in the Golgi apparatus. Alternatively, the association of IGF-II with another IGFBP would inhibit this binding and lead to its autocrine or intracrine mitogenic action via the IGF-I receptor.
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Dubois, V., Couissi, D., Schonne, E., Schneider, Y.-J., Remacle, C., & Trouet, A. (1993). Estrogen and insulin modulation of intracellular insulin-like growth factor binding proteins in human breast cancer cells: possible involvement in lysosomal hydrolases oversecretion. Biochemical and Biophysical Research Communications, 192(1), 295-301. https://doi.org/10.1006/bbrc.1993.1413 (Original work published 1993)