Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus

Dutka Malen, Sylvie;Blaimont, Brigitte;Wauters, Georges;Courvalin, Patrice
(1994) Antimicrobial Agents and Chemotherapy — Vol. 38, n° 7, p. 1675-1677 (1994)

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Authors
  • Dutka Malen, Sylvie
    Author
  • Blaimont, BrigitteUCLouvain
    Author
  • Wauters, GeorgesUCLouvain
    Author
  • Courvalin, Patrice
    Author
Abstract
Enterococcus gallinarum BM4231 and Enterococcus casseliflavus BM4232, isolated from the feces of a patient under oral therapy with vancomycin, were resistant to high levels of vancomycin (MICs of >256 mu g/ml) and teicoplanin (MICs of 128 and 64 mu g/ml, respectively). This phenotype is new for these bacterial species that are naturally resistant to low levels of vancomycin and appears to be due to in vivo acquisition of plasmid pIP218 carrying the vanA gene cluster.
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Dutka Malen, S., Blaimont, B., Wauters, G., & Courvalin, P. (1994). Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus. Antimicrobial Agents and Chemotherapy, 38(7), 1675-1677. https://doi.org/10.1128/aac.38.7.1675 (Original work published 1994)