Regeneration of lesioned cholinergic septal neurons of the adult rat can be promoted by peripheral nerve grafts and a fibrin-fibronectin-containing matrix of peripheral regeneration chambers.

Knoops, Bernard;Ponsar, C.;Hubert, I.;van den Bosch de Aguilar, P
(1993) Brain Research Bulletin — Vol. 30, n° 3-4, p. 433-437 (1993)

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Authors
  • Knoops, BernardUCLouvain
    Author
  • Ponsar, C.
    Author
  • Hubert, I.
    Author
  • van den Bosch de Aguilar, P
    Author
Abstract
Axonal regeneration of septal cholinergic neurons was examined after lesion of the septohippocampal pathway of the adult rat and implantation of tubes containing peripheral cellular or acellular substrates. After empty tube implantation, no regenerated structures were observed in the conduit. However, after implanting tubes filled with sections of predegenerated sciatic nerves or a fibrin-fibronectin-containing matrix provided by peripheral regeneration chambers, numerous regenerated axons were detected 6 weeks after the operation. At the electron microscopic level, regenerated axons were observed in the grafted sciatic nerves in contact with Schwann cells but also in contact with astrocytes which were able to migrate and send processes into the graft. After fibrin-fibronectin-containing-matrix implantation, the regenerated structure between septum and hippocampus was composed mainly of fibroblasts, astrocytes, and regenerated axons associated to these central glial cells.
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Knoops, B., Ponsar, C., Hubert, I., & van den Bosch de Aguilar, P. (1993). Regeneration of lesioned cholinergic septal neurons of the adult rat can be promoted by peripheral nerve grafts and a fibrin-fibronectin-containing matrix of peripheral regeneration chambers. Brain Research Bulletin, 30(3-4), 433-437. https://doi.org/10.1016/0361-9230(93)90275-G (Original work published 1993)