Methodological approaches influencing cellular uptake and cyto-(geno) toxic effects of nanoparticles.

Gonzalez, Laetitia;Corradi, Sara;Thomassen, Leen C J;Martens, Johan A;Kirsch-Volders, Micheline;et.al.
(2011) Journal of Biomedical Nanotechnology — Vol. 7, n° 1, p. 3-5 (2011)

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Authors
  • Gonzalez, Laetitia
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  • Corradi, Sara
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  • Thomassen, Leen C J
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  • Martens, Johan A
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  • Lison, Dominiqueorcid-logoUCLouvain
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  • Kirsch-Volders, Micheline
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Abstract
Methods are needed to assess cytotoxicity and genotoxicity of nanoparticles (NPs). The influence of serum and the use of cytochalasin-B were assessed on the cellular uptake of amorphous silica NPs (SNPs) and their biological effects. Our observations indicate that some methodological approaches may modulate the outcome of the assay. Therefore the experimental design and choice of the assays are of great importance in nanotoxicology.
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Gonzalez, L., Corradi, S., Thomassen, L. C. J., Martens, J. A., Cundari, E., Lison, D., & Kirsch-Volders, M. (2011). Methodological approaches influencing cellular uptake and cyto-(geno) toxic effects of nanoparticles. Journal of Biomedical Nanotechnology, 7(1), 3-5. https://doi.org/10.1166/jbn.2011.1172 (Original work published 2011)