Despite benefits of cardiac resynchronization therapy (CRT) in patients with severe but less symptomatic heart failure, approximately 30% of patients do not fully respond to treatment. We hypothesized that a combined assessment of left ventricular (LV) dyssynchrony and contractile function by strain-based imaging would identify patients who would most benefit from CRT.
Knappe, D., Pouleur, A.-C., Shah, A. M., Cheng, S., Uno, H., Hall, W. J., Bourgoun, M., Foster, E., Zareba, W., Goldenberg, I., McNitt, S., Moss, A. J., & Solomon, S. D. (2011). Dyssynchrony, contractile function, and response to cardiac resynchronization therapy. Circulation. Heart Failure, 4(4), 433-440. https://doi.org/10.1161/CIRCHEARTFAILURE.111.962902 (Original work published 2011)