Laccases: a never-ending story

Giardina, Paola;Faraco, Vincenza;Pezzella, Cinzia;Piscitelli, Alessandra;Sannia, Giovanni;et.al.
(2010) Cellular and Molecular Life Sciences — Vol. 67, n° 3, p. 369-385 (2010)

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Authors
  • Giardina, PaolaComplesso Univ Monte S Angelo, Dipartimento Chim Organ & Biochem, I-80126 Naples, Italy
    Author
  • Faraco, VincenzaComplesso Univ Monte S Angelo, Dipartimento Chim Organ & Biochem, I-80126 Naples, Italy
    Author
  • Pezzella, CinziaComplesso Univ Monte S Angelo, Dipartimento Chim Organ & Biochem, I-80126 Naples, Italy
    Author
  • Piscitelli, AlessandraComplesso Univ Monte S Angelo, Dipartimento Chim Organ & Biochem, I-80126 Naples, Italy
    Author
  • Vanhulle, SophieUCLouvain
    Author
  • Sannia, GiovanniComplesso Univ Monte S Angelo, Dipartimento Chim Organ & Biochem, I-80126 Naples, Italy
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Abstract
Laccases (benzenediol:oxygen oxidoreductases, EC 1.10.3.2) are blue multicopper oxidases that catalyze the oxidation of an array of aromatic substrates concomitantly with the reduction of molecular oxygen to water. In fungi, laccases carry out a variety of physiological roles during their life cycle. These enzymes are being increasingly evaluated for a variety of biotechnological applications due to their broad substrate range. In this review, the most recent studies on laccase structural features and catalytic mechanisms along with analyses of their expression are reported and examined with the aim of contributing to the discussion on their structure-function relationships. Attention has also been paid to the properties of enzymes endowed with unique characteristics and to fungal laccase multigene families and their organization.
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Giardina, P., Faraco, V., Pezzella, C., Piscitelli, A., Vanhulle, S., & Sannia, G. (2010). Laccases: a never-ending story. Cellular and Molecular Life Sciences, 67(3), 369-385. https://doi.org/10.1007/s00018-009-0169-1 (Original work published 2010)