Functionalised medium-ring systems of various sizes can be efficiently prepared by a novel approach that embodies a radical-induced fragmentation of bicyclic P-hydroxy ketones, followed by a second radical-coupling reaction. The unexpected reactivity of ot-keto radicals is also discussed. © 2005 Elsevier Ltd. All rights reserved.
De Dobbeleer, C., Ates, A., Vanherk, J., & Marko, I. (2005). Efficient access to functionalised medium-ring systems by radical fragmentation/radical addition to alpha-iodoketones. Tetrahedron Letters, 46(22), 3889-3893. https://doi.org/10.1016/j.tetlet.2005.03.200 (Original work published 2005)