T-cell responses of vaccinated cancer patients.
(2003) Current Opinion in Immunology — Vol. 15, n° 2, p. 131-137 (2003)
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- Abstract
- Following vaccination with defined tumor antigens that are recognized by T cells, a small proportion of cancer patients display tumor regressions. Several reports describe anti-vaccine T-cell responses, evaluated with a variety of methods, for example, by assessing T-cell function or expression of specific TCR. However, a correlation between these T-cell responses and the tumor regressions has not yet been established. It appears that some patients display tumor regression with an unexpectedly low frequency of anti-vaccine T cells.
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Citations
Coulie, P., & van der Bruggen, P. (2003). T-cell responses of vaccinated cancer patients. Current Opinion in Immunology, 15(2), 131-137. https://doi.org/10.1016/S0952-7915(03)00009-8 (Original work published 2003)