Can mesenchymal stem cell lysate reverse aging?
(2018) Aging — Vol. 10, n° 10, p. 2900-2910 (2018)
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- Recent findings regarding uses of adipose-derived mesenchymal stem cell (MSC)-lysate on weight loss and improved glucose tolerance in mice on a high-fat diet suggest an encouraging possibility of using MSC lysate for an anti-aging intervention in humans. However, weight loss and lipopenia during late life can be as life-threatening as hyperglycemia during early adulthood. For this 3-year lifelong experiment, a total of 92 rats were randomized into the vehicle-injected group (F=22; M=24) and the MSC lysate injected group (F=22, M=24). We examined longevity, spontaneous locomotor activity, and body composition in rats maintained on a normal diet and received an intermittent treatment of human adipose-derived MSC lysate (3 times a week, 11 times a month given every second month), starting at 12 months of age until natural death. In substantiating previous knowledge regarding the effects of long-term MSC lysate treatments on fat loss and insulin resistance, the present findings also highlighted a shortened average lifespan, a longer inactive time, and a greater bone loss with a relative increase of lean mass in MSC lysate rats with respect to controls. Conclusion: Our data suggest that MSC lysate treatments stimulate disparity in tissue development and produce a cachexia-like effect to decrease longevity.
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Hsu, M.-F., Yu, S.-H., Chuang, S.-J., Kuo, T. K.-C., Singal, P. K., Huang, C.-Y., Kao, C.-L., & Kuo, C.-H. (2018). Can mesenchymal stem cell lysate reverse aging? Aging, 10(10), 2900-2910. https://doi.org/10.18632/aging.101595 (Original work published 2018)