A Building Block
Strategy for Construction of C(sp3)–SCF3 Bonds via Nickel-Catalyzed 1,2-Difunctionalization
of Trifluoromethylthiolated Alkenes

Vanderbiest, Xavier; Riant, Olivier

doi:10.1021/acs.orglett.6c02895

A Building Block Strategy for Construction of C(sp3)–SCF3 Bonds via Nickel-Catalyzed 1,2-Difunctionalization of Trifluoromethylthiolated Alkenes

Vanderbiest, Xavier

;

Riant, Olivier

(2026) Organic Letters — Vol. 28, n° 30, p. 9840-9845 (2026)

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Authors

Vanderbiest, XavierUCLouvain
Author
Riant, OlivierUCLouvain
Author

Abstract

The trifluoromethylthiol (SCF3) group has emerged as a valuable motif in medicinal chemistry owing to its strong electron-withdrawing nature and its high lipophilicity. Despite significant advances in SCF3 incorporation into a variety of molecules, the construction of C(sp3)–SCF3 bonds remains a notable challenge. Herein, we present a Ni-catalyzed 1,2-difunctionalization using a newly designed SCF3-containing synthon readily accessible in a single step.

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UCLouvainSST/IMCN/MOST - Molecular Chemistry, Materials and Catalysis

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Vanderbiest, X., & Riant, O. (2026). A Building Block Strategy for Construction of C(sp3)–SCF3 Bonds via Nickel-Catalyzed 1,2-Difunctionalization of Trifluoromethylthiolated Alkenes. Organic Letters, 28(30), 9840-9845. https://doi.org/10.1021/acs.orglett.6c02895 (Original work published 2026)