Bicyclo[2.2-1]heptanes as novel triple re-uptake inhibitors for the treatment of depression

Axford, L;Boot, JR;Hotten, TM;Keenan, M;Vivien, V;et.al.
(2003) Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology — Vol. 13, n° 19, p. 3277-3280 (2003)

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Authors
  • Axford, L
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  • Boot, JR
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  • Hotten, TM
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  • Keenan, M
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  • Vivien, V
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Abstract
A series of substituted naphthyl containing chiral [2.2.1] bicycloheptanes were prepared utilizing asymmetric Diels-Alder chemistry. This paper describes structure-activity relationships in this series. The N-methyl 2-naphthyl analogue (16d) and its desmethyl analogue (17d) are active triple re-uptake inhibitors both in vivo and in vitro. (C) 2003 Elsevier Ltd. All rights reserved.
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Axford, L., Boot, J., Hotten, T., Keenan, M., Martin, F., Milutinovic, S., Moore, N., O’Neill, M., Pullar, I., Tupper, D., Van Belle, K., & Vivien, V. (2003). Bicyclo[2.2-1]heptanes as novel triple re-uptake inhibitors for the treatment of depression. Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, 13(19), 3277-3280. https://doi.org/10.1016/S0960-894X(03)00660-7 (Original work published 2003)