Exploring the genetic driver events of eccrine poromas and porocarcinomas: a retrospective, cross-institutional study of 54 cases.

Arends, Mark J;Del Castillo Velasco-Herrera, Martin;Cheema, Saamin;Wong, Kim;Adams, David J;et.al.
(2025) British Journal of Dermatology — Vol. 192, n° 4, p. 745-747 (2025)

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Abstract
We have comprehensively characterized the mutational landscape of eccrine poroma (EP) and eccrine porocarcinoma (EPC), uncovering novel molecular events and delineating different pathways of tumorigenesis underlying these tumours. EPs are driven largely by oncogenic fusion genes, whereas EPCs are driven largely by somatic mutations affecting various pathways, with a subset driven by fusion genes as the first oncogenic driver, and somatic mutations representing secondary events contributing to progression of the tumour. Fusion genes in EP predominantly involve , while those in EPC preferentially involve gene family members.
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  • Wellcome Sanger InstituteExperimental Cancer Genetics

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Arends, M. J., Del Castillo Velasco-Herrera, M., Cheema, S., Wong, K., Boccacino, J. M., Vermes, I., Roberts, K., Anderson, E., van der Horst, M. P. J., de Saint Aubain, N., Alomari, A. K., Monteagudo, C., Billings, S. D., Frew, D., Clarke, E., Merchant, W., Rajan, N., Ferguson, P., Mogler, C., et al. (2025). Exploring the genetic driver events of eccrine poromas and porocarcinomas: a retrospective, cross-institutional study of 54 cases. British Journal of Dermatology, 192(4), 745-747. https://doi.org/10.1093/bjd/ljae447 (Original work published 2025)