Translational study of the role of secretory IgA in chronic rhinosinusitis using innovative experimental models
(2025)
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- Abstract
- Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease of the upper airways. This thesis explores the role of secretory IgA (s-IgA) in CRS pathophysiology using an integrated translational approach. Combining human sinonasal tissue analyses with innovative murine models of eosinophilic and neutrophilic CRS, the study reveals impaired epithelial pIgR/IgA expression and s-IgA in secretions in patients, as well as divergent effects of s-IgA deficiency on inflammation across endotypes. Moreover, we found that s-IgA seem to bind nasal microbiome members differently among patients and controls, suggesting differences in immune response towards commensals. These findings suggest an important and currently neglected role of s-IgA in driving CRS.
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Sanchez Montalvo, A. (2025). Translational study of the role of secretory IgA in chronic rhinosinusitis using innovative experimental models. https://hdl.handle.net/2078.5/245837