(en) [Neurological implications of SARS-CoV-2 infection] A steadily increasing number of cases with neurological manifestations that are potentially related to COVID-19 are being reported in the literature. These most often include sudden anosmia, headache, encephalopathy, and stroke. The pathophysiological mechanisms underlying "Neuro-COVID" remain largely unknown, while the viral genome is very rarely detected in the cerebrospinal fluid. A study currently ongoing at the Cliniques universitaires Saint-Luc is aimed at investigating COVID-19 associated cerebrospinal fluid changes as well as immunohistochemical evidences of olfactory neuroepithelial cells direct viral infection and evidencing a direct infection of olfactory neuroepithelial cells.
Maggi, P., Guilmot, A., Maldonado Slootjes, S., Huart, C., Hanseeuw, B., Duprez, T., De Greef, J., Belkhir, L., Yombi, J. C., Ivanoiu, A., & Van Pesch, V. (2020). Implications neurologiques de l’infection à SARS-CoV-2. Louvain médical, 139(05-06), 312-314. https://hdl.handle.net/2078.5/246011 (Original work published 2020)