Successful management of a severe anti-M alloimmunization during pregnancy.

Hubinont, Corinne;Delens, Gilda;Vanalbada De Haan Hettema, Julie;Lambert, Catherine;Biard, Jean-Marc;et.al.
(2017) European Journal of Obstetrics & Gynecology and Reproductive Biology — Vol. 217, p. 175-176 (2017)

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Authors
  • Author
  • Delens, GildaUCLouvain
    Author
  • Vanalbada De Haan Hettema, JulieUCLouvain
    Author
  • Author
  • Debauche, ChristianUCLouvain
    Author
  • Biard, Jean-MarcUCLouvain
    Author
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Abstract
We report the successful outcome of a patient with anti-M antibodies with a previous history of severe hemolysis of erythrocytes. Serial plasma exchange from the first trimester combined with ultrasound monitoring of the fetal middle cerebral artery blood velocity was implemented. This management allowed a favorable pregnancy outcome of an infant born by an elective caesarean section at 32 weeks 6/7 with a normal Apgar score at 8/9/10. The other therapeutic alternatives such as intravenous immunoglobulin and in utero fetal blood transfusions are discussed.
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Citations

Hubinont, C., Delens, G., Vanalbada De Haan Hettema, J., Lambert, C., Debauche, C., & Biard, J.-M. (2017). Successful management of a severe anti-M alloimmunization during pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology, 217, 175-176. https://doi.org/10.1016/j.ejogrb.2017.07.024 (Original work published 2017)