Cell replacement strategies aimed at reconstitution of the β-cell compartment in type 1 diabetes
(2014) Diabetes — Vol. 63, n° 5, p. 1433-1444 (2014)
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- Abstract
- Emerging technologies in regenerative medicine have the potential to restore the β-cell compartment in diabetic patients, thereby overcoming the inadequacies of current treatment strategies and organ supply. Novel approaches include: 1) Encapsulation technology that protects islet transplants from host immune surveillance; 2) stem cell therapies and cellular reprogramming, which seek to regenerate the depleted β-cell compartment; and 3) whole-organ bioengineering, which capitalizes on the innate properties of the pancreas extracellular matrix to drive cellular repopulation. Collaborative efforts across these subfields of regenerative medicine seek to ultimately produce a bioengineered pancreas capable of restoring endocrine function in patients with insulin-dependent diabetes.
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Citations
Orlando, G., Gianello, P., Salvatori, M., Stratta, R. J., Soker, S., Ricordi, C., & Domínguez-Bendala, J. (2014). Cell replacement strategies aimed at reconstitution of the β-cell compartment in type 1 diabetes. Diabetes, 63(5), 1433-1444. https://doi.org/10.2337/db13-1742 (Original work published 2014)