A formula is given for the discriminant of the tensor product of the canonical involution on a quaternion algebra and an orthogonal involution on a central simple algebra of degree divisible by 4. As an application, an alternative proof of Shapiro's "Pfister factor conjecture" is given for tensor products of at most five quaternion algebras.
Serhir, A., & Tignol, J.-P. (2004). The discriminant of a decomposable symplectic involution. Journal of Algebra, 273(2), 601-607. https://doi.org/10.1016/j.jalgebra.2003.05.007 (Original work published 2004)