Protection of 2,6-diaminopurine 2'-deoxyriboside

Luyten, I;Vanaerschot, A.;Rozenski, J.;Busson, Roger;Herdewijn, P.
(1997) XII International Round Table on Nucleosides, Nucleotides and their Biological Applications - Making Drugs Out of Nucleosides and Oligonucleotides — Location: LA JOLLA(Ca) (15.September.1996)

Files

No attached file found for this publication.

Details

Authors
  • Luyten, I
    Author
  • Vanaerschot, A.
    Author
  • Rozenski, J.
    Author
  • Busson, RogerKUL
    Author
  • Herdewijn, P.
    Author
Abstract
Protection of both amine moieties of 2,6-diaminopurine 2'-deoxyriboside as a dimethylformamidine group did not proove feasable, while protection with a phenoxyacetyl group afforded only a mono-protected analogue 5. This analogue can be incorporated into oligonucleotides without difficulties. However, oligonucleotides with diaminopurine substituted for adenine did not yield more stable duplexes for the two sequences tested here.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Luyten, I., Vanaerschot, A., Rozenski, J., Busson, R., & Herdewijn, P. (1997). Protection of 2,6-diaminopurine 2′-deoxyriboside. Nucleosides and Nucleotides, 16(7-9), 1649-1652. https://doi.org/10.1080/07328319708006247 (Original work published 1997)