Clonal Rearrangement of the T-cell Receptor Beta-chain Gene in the Pleural Fluid of a Patient With Thymoma
(1993) Nouvelle Revue Francaise d’Hematologie - Journal of Experimental and Clinical Hematology — Vol. 35, n° 2, p. 121-124 (1993)
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- Abstract
- Thymoma is generally considered as an epithelial malignancy surrounded by lymphocytes not belonging to the tumour. This report documents a case of malignant thymoma associated with a lymphocytic pleural effusion. The pleural lymphocytes were mature T-cells, a small proportion of which were shown to have a monoclonal rearrangement of the beta-chain of the T-cell receptor. On the contrary, the lymphocytes of peripheral blood exhibited a germline configuration. The nature of the monoclonal population found in the pleural fluid is discussed and if the cells are of thymic origin their clonal configuration may point to a neoplastic nature of lymphocytes infiltrating malignant thymoma. Alternatively, he clonal T-cell subpopulation may result from an aberrant immunological response to the thymoma.
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Delannoy, A., Philippe, M., Hamels, J., & Beauduin, M. (1993). Clonal Rearrangement of the T-cell Receptor Beta-chain Gene in the Pleural Fluid of a Patient With Thymoma. Nouvelle Revue Francaise d’Hematologie - Journal of Experimental and Clinical Hematology, 35(2), 121-124. https://hdl.handle.net/2078.5/147037 (Original work published 1993)