Case report: Personalized triple phage-antibiotic combination therapy to rescue necrotizing fasciitis caused by Panton-Valentine leukocidin-producing MRSA in a 12-year-old boy.

Van Nieuwenhuyse, Brieuc;Balcaen, Mathilde;Chatzis, Olga;Haenecour, Astrid;Van der Linden, Dimitri;et.al.
(2024) Frontiers in Cellular and Infection Microbiology — Vol. 14, p. 1354681 [1-9] (2024)

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Abstract
Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant (MRSA) in a 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against and , eventually leading to full recovery with no reported adverse events.
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Van Nieuwenhuyse, B., Balcaen, M., Chatzis, O., Haenecour, A., Derycke, E., Detaille, T., Clément de Cléty, S., Boulanger, C., Belkhir, L., Yombi, J. C., De Greef, J., Cornu, O., Docquier, P.-L., Lentini, A., Menten, R., Rodriguez-Villalobos, H., Verroken, A., Djebara, S., Merabishvili, M., et al. (2024). Case report: Personalized triple phage-antibiotic combination therapy to rescue necrotizing fasciitis caused by Panton-Valentine leukocidin-producing MRSA in a 12-year-old boy. Frontiers in Cellular and Infection Microbiology, 14, 1354681 [1-9]. https://doi.org/10.3389/fcimb.2024.1354681 (Original work published 2024)