The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells
(2007) FEBS Letters — Vol. 581, n° 22, p. 4235-4240 (2007)
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- Abstract
- The control of glucagon secretion by pancreatic alpha-cells is poorly understood, largely because of the difficulty to recognize living alpha-cells. We describe a new mouse model, referred to as GluCre-ROSA26EYFP (or GYY), allowing easy alpha-cell identification because of specific expression of EYFP. GYY mice displayed normal glycemic control during a fasting/refeeding test or intraperitoneal insulin injection. Glucagon secretion by isolated islets was normally inhibited by glucose and stimulated by adrenaline. [Ca(2+)](c) responses to arginine, adrenaline, diazoxide and tolbutamide, were similar in GYY and control mice. Hence, this new mouse model is a reliable and powerful tool to specifically study alpha-cells.
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Quoix, N., Cheng-Xue, R., Guiot, Y., Herrera, P. L., Henquin, J.-C., & Gilon, P. (2007). The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells. FEBS Letters, 581(22), 4235-4240. https://doi.org/10.1016/j.febslet.2007.07.068 (Original work published 2007)