Severe Diltiazem Poisoning With Intestinal Pseudoobstruction - Case-report and Toxicological Data

Fauville, JP.;Hantson, Philippe;Honore, P.;Belpaire, F.;Mahieu, P.;et.al.
(1995) Journal of Toxicology. Clinical Toxicology — Vol. 33, n° 3, p. 273-277 (1995)

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  • Fauville, JP.
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  • Honore, P.
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  • Belpaire, F.
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  • Mahieu, P.
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Abstract
This case report concerns a 30-year-old man who survived a 4.2 g diltiazem overdose. He sustained vasoplegic shock with a junctional escape rhythm which required high doses of norepinephrine and epinephrine. Among other complications, ileus with paralytic intestinal pseudo-obstruction developed on day three. Cecal distention was demonstrated by abdomen computed tomodensitometry. The ileus resolved on day seven following the poisoning. Diltiazem plasma concentrations were determined during the first three days. The possible role of other medications, activated charcoal and sufentanil, is noted.
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Fauville, JP., Hantson, P., Honore, P., Belpaire, F., Rosseel, MT., & Mahieu, P. (1995). Severe Diltiazem Poisoning With Intestinal Pseudoobstruction - Case-report and Toxicological Data. Journal of Toxicology. Clinical Toxicology, 33(3), 273-277. https://doi.org/10.3109/15563659509017999 (Original work published 1995)