Can inhalation agents be used in the presence of a child with myopathy?
(2010) Current Opinion in Anaesthesiology — Vol. 23, n° 3, p. 348-355 (2010)
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- Abstract
- PURPOSE OF REVIEW: Anaesthesia for a child with a muscle disease is always challenging because there is a risk of malignant hyperthermia, rhabdomyolysis or hypermetabolic reaction if a halogenated agent is used. Ongoing progress in genetics helps in clarifying the link between malignant hyperthermia (a calcium channelopathy) and muscle diseases. RECENT FINDINGS: We provide a summary of the most recent clinical, pathophysiological and genetic information on those risks when the diagnosis is known or suspected preoperatively. Some simple clues are also given to help make a decision in the presence of an infant or child with hypotonia or motor delay but no diagnosis. SUMMARY: Only a few muscle diseases are really associated with a risk of malignant hyperthermia. The risk of rhabdomyolysis is more difficult to clarify and a multicentric database would be useful to evaluate the risk/benefit ratio of all anaesthetic drugs in patients with muscle diseases.
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Veyckemans, F. (2010). Can inhalation agents be used in the presence of a child with myopathy? Current Opinion in Anaesthesiology, 23(3), 348-355. https://doi.org/10.1097/ACO.0b013e3283393977 (Original work published 2010)