Separate isolation of cells from nodules and surrounding parenchyma of the same precancerous rat liver: biochemical and cytochemical characterization.
(1980) Toxicology — Vol. 18, n° 3, p. 225-232 (1980)
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- Various enzyme and metabolic alterations have been observed in the hyperplastic nodules which appear during the hepatocarcinogenesis. These alterations have been mainly specified by histochemical observations. In this report, a technique of hepatocyte isolation is described which enables the separation of 2 cellular fractions, respectively, from the nodules and from the surrounding parenchyma of the same liver of a rat previously treated with a hepatocarcinogen. Such a technique allowed parallel analysis of both cellular populations by biochemical and cytochemical techniques.
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de Gerlache, J., Lans, M., Taper, H., & Roberfroid, M. (1980). Separate isolation of cells from nodules and surrounding parenchyma of the same precancerous rat liver: biochemical and cytochemical characterization. Toxicology, 18(3), 225-232. https://hdl.handle.net/2078.5/82495 (Original work published 1980)