Expression of Mage Genes in Primary and Metastatic Cutaneous Melanoma
(2004) International Journal of Cancer — Vol. 63, n° 3, p. 375-380 (2004)
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- et. al.
- Abstract
- Human genes MAGE-1 and MAGE-3 code for antigens that are recognized on melanoma cells by autologous cytolytic T lymphocytes. These antigens may constitute useful targets for specific anti-tumor immunization of cancer patients, since genes MAGE-1 and MAGE-3 are expressed in a number of tumors of different histological types, but are not expressed in normal adult tissues other than testis. This also applies to genes MAGE-2 and MAGE-4, which are closely related to MAGE-1 and MAGE-3. We have analyzed the expression of these 4 MAGE genes in cutaneous melanoma. Sixteen of 100 primary tumors vs. 69 (48%) of 145 metastases from individual patients expressed MAGE-1. Similar differences in the frequency of gene expression between primary and metastatic tumor samples were observed for MAGE-2, MAGE-3, and MAGE-4. MAGE expression in primary tumors was correlated with tumor thickness: there was a significantly increased frequency in the expression of MAGE-1, -2 and -3 in tumors of greater thickness. Benign and dysplastic nevi, as well as in site melanomas, did not express any of the 4 MAGE genes. (C) 1995 Wiley-Liss, Inc.
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Brasseur, F., Vanwijck, R., Humblet, Y., Bourlond, A., Suciu, S., Lachapelle, J.-M., Boon, T., & et al. (2004). Expression of Mage Genes in Primary and Metastatic Cutaneous Melanoma. International Journal of Cancer, 63(3), 375-380. https://doi.org/10.1002/ijc.2910630313 (Original work published 2004)