Reversible cholestasis with bile duct injury following azathioprine therapy. A case report.
(1991) Liver — Vol. 11, n° 2, p. 89-93 (1991)
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- Abstract
- A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy. Liver biopsy showed cholestasis with both cytological and architectural alterations of interlobular bile ducts. Azathioprine withdrawal resulted after 7 weeks in the resolution of clinical and biochemical abnormalities. It is believed that this is the first reported case of reversible azathioprine-induced cholestasis associated with histological evidence of bile duct injury.
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Horsmans, Y., Rahier, J., & Geubel, A. (1991). Reversible cholestasis with bile duct injury following azathioprine therapy. A case report. Liver, 11(2), 89-93. https://hdl.handle.net/2078.5/75613 (Original work published 1991)