Magnetic levitation as a tool for separation : separating cocrystals from crystalline phases of individual compounds

Matheys, Chloé;Tumanova, Natalia;Leyssens, Tom;Myerson, Allan S.
(2016) Crystal Growth & Design — Vol. 16, n° 9, p. 5549-5553 (2016)

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  • Matheys, ChloéUCLouvain
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  • Tumanova, NataliaUCLouvain
    Author
  • Leyssens, TomUCLouvain
    Author
  • Myerson, Allan S.Massachusetts Institute of Technology
    Author
Abstract
In this contribution, we extend the phase separation abilities of magnetic levitation (MagLev), applying it to cocrystal systems. Most of these systems show incongruent solubility in solution. Crystallization from an equimolar mixture often leads to the crystallization of both cocrystal and coformer (one of the individual cocrystal formers). Using carbamazepine/salicylic acid and carbamazepine/camphoric acid systems, we demonstrated that MagLev is an efficient and straightforward tool for phase separation in these systems.
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Matheys, C., Tumanova, N., Leyssens, T., & Myerson, A. S. (2016). Magnetic levitation as a tool for separation : separating cocrystals from crystalline phases of individual compounds. Crystal Growth & Design, 16(9), 5549-5553. https://doi.org/10.1021/acs.cgd.6b01018 (Original work published 2016)