Trifluoromethylated Pyrimidines Starting From Beta-trifluoroacetyl-lactams, Beta-trifluoroacetyl-lactone and Beta-trifluoroacetyl-cyclanone

Bouillon, JP.;Bouillon, V.;Wynants, C.;Janousek, Z.;Viehe, HG.
(1994) Heterocycles — Vol. 37, n° 2, p. 915-932 (1994)

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  • Bouillon, JP.
    Author
  • Bouillon, V.
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  • Wynants, C.
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  • Janousek, Z.
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  • Viehe, HG.
    Author
Abstract
A synthesis of trifluoromethylated pyrimidines from beta-trifluoroacetyl-lactams and -benzolactams is accomplished by reaction with benzamidine as bis-nucleophile. This condensation is also extended to cyclic trifluoromethylated 1,3-diketones and 3-aroyl-2-pyrrolidinones.
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Bouillon, JP., Bouillon, V., Wynants, C., Janousek, Z., & Viehe, HG. (1994). Trifluoromethylated Pyrimidines Starting From Beta-trifluoroacetyl-lactams, Beta-trifluoroacetyl-lactone and Beta-trifluoroacetyl-cyclanone. Heterocycles, 37(2), 915-932. https://doi.org/10.3987/COM-93-S84 (Original work published 1994)