Fomepizole alone for severe infant ethylene glycol poisoning.
(2004) Pediatric Critical Care Medicine — Vol. 5, n° 4, p. 1-3 (2004)
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- Abstract
- OBJECTIVE: To report a case of a massive ingestion of ethylene glycol in an infant successfully treated by fomepizole without hemodialysis. DESIGN: Descriptive case report. SETTING: Pediatric intensive care unit. PATIENT: A 5-mo-old boy who ingested 200 mL of an antifreeze solution. INTERVENTIONS: Antidotal therapy with a total of seven doses of fomepizole administered intravenously with an interval of 12 hrs (15 mg/kg as loading dose, then 10 mg/kg). Hemodialysis was not performed. MEASUREMENTS AND MAIN RESULTS: Iterative determination of ethylene glycol concentration was obtained in blood and urine. Kinetics were calculated for ethylene glycol and fomepizole elimination. The infant made a complete recovery with no change in renal function. CONCLUSIONS: Although not yet approved for this indication in the child, fomepizole seemed safe and effective in a case of severe ethylene glycol poisoning, without the need for hemodialysis.
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Citations
Detaille, T., Wallemacq, P., Clément de Cléty, S., Vanbinst, R., Dembour, G., & Hantson, P. (2004). Fomepizole alone for severe infant ethylene glycol poisoning. Pediatric Critical Care Medicine, 5(4), 1-3. https://doi.org/10.1097/01.PCC.0000128600.17670.FF (Original work published 2004)