Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms.
(2021) Cells — Vol. 10, n° 2, p. 477 [1-22] (2021)
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- Authors
Mendes-Ferreira, Pedro 
Perros, Frédéric
- Abstract
- Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease that is caused by the progressive occlusion of the distal pulmonary arteries, eventually leading to right heart failure and death. Almost 40% of patients with PAH are iron deficient. Although widely studied, the mechanisms linking between PAH and iron deficiency remain unclear. Here we review the mechanisms regulating iron homeostasis and the preclinical and clinical data available on iron deficiency in PAH. Then we discuss the potential implications of iron deficiency on the development and management of PAH.
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Citations
Quatredeniers, M., Mendes-Ferreira, P., Santos Ribeiro, D., Nakhleh, M. K., Ghigna, M.-R., Cohen-Kaminsky, S., & Perros, F. (2021). Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms. Cells, 10(2), 477 [1-22]. https://doi.org/10.3390/cells10020477 (Original work published 2021)