Cellular and molecular effects of spaceflight and space-simulated environments on human in vitro models
(2012)
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- Abstract
- (en) During spaceflight, a wide variety of physical (radiation and microgravity) and psychological stress factors (such as isolation, heavy workload and disturbed sleep pattern) can adversely affect astronauts' health by impairing their immune system. Through additive or synergetic interaction, several of these factors might compromise astronauts' resistance to infections and other diseases. In this PhD study, ground-based models were used to simulate space conditions, including radiation (X-rays, mixture of neutrons/γ-rays) and microgravity. Using in vitro experiments, different cell types (immune cells, fibroblasts and endothelial cells) were exposed to these space-simulated conditions in order to better understand the biological and molecular mechanisms (including DNA damage and repair, apoptosis, cytokine secretion, and gene expression) induced by space stressors.
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Citations
Ghardi, M. (2012). Cellular and molecular effects of spaceflight and space-simulated environments on human in vitro models. https://hdl.handle.net/2078.5/91628