LC-MS analysis in the e-beam and gamma radiolysis of metoprolol tartrate in aqueous solution: Structure elucidation and formation mechanism of radiolytic products
(2006) Radiation Physics and Chemistry — Vol. 75, n° 9, p. 977-989 (2006)
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- E-beam and gamma products from the radiolysis of aqueous solutions of (+/-)-metoprolol tartrate, saturated in nitrogen, are analyzed by HPLC with on-line mass and UV detectors. The structures of 10 radiolytic products common to e-beam and gamma irradiations are elucidated by comparing their fragmentation pattern to that of (+/-)-metoprolot. Two of the radiolytic products are also metabolites. Different routes for the formation of the radiolytic products are proposed. (c) 2006 Published by Elsevier Ltd.
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Slegers, C., Maquille, A., Deridder, W., Sonveaux, E., Jiwan, J.-L. H., & Tilquin, B. (2006). LC-MS analysis in the e-beam and gamma radiolysis of metoprolol tartrate in aqueous solution: Structure elucidation and formation mechanism of radiolytic products. Radiation Physics and Chemistry, 75(9), 977-989. https://doi.org/10.1016/j.radphyschem.2006.02.001 (Original work published 2006)