Prevalence of HIV co-receptor polymorphisms in HIV-infected patients and uninfected volunteers in Luxembourg.
(2002) HIV Clinical Trials — Vol. 3, n° 3, p. 195-201 (2002)
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- PURPOSE: To describe the prevalence of nine HIV-1 co-receptor polymorphisms in Luxembourg (CCR5-Delta 32, CCR5-58755-A/G, CCR5m303, CCR5-59029-A/G, CCR2-64I, CCR5-59653-C/T, CX(3) CR1-V249I, CX(3) CR1-T280M, and SDF1-3'A) in 288 HIV-1-infected patients and in 158 uninfected, healthy volunteers. METHOD: The presence of mutations was detected using PCR-restriction fragment length polymorphism (RFLP)-based methods. RESULTS: We did not find any significant differences in genotype distributions and allele frequencies between infected and uninfected participants in Luxembourg. The distribution of genotypes agreed in all groups with Hardy-Weinberg predicted proportions. CCR5-Delta 32 was significantly associated with HIV-1-infected slow progressor patients. CONCLUSION: Overall, allele frequencies were comparable to frequencies reported in previous studies in Caucasian populations.
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Roman, F., Franck, N., Burgy, C., Servais, J., Zimmer, J.-M., Mossong, J., Goubau, P., Schneider, F., Hemmer, R., & Schmit, J.-C. (2002). Prevalence of HIV co-receptor polymorphisms in HIV-infected patients and uninfected volunteers in Luxembourg. HIV Clinical Trials, 3(3), 195-201. https://doi.org/10.1310/5EY7-2KVG-FE6L-6VWH (Original work published 2002)