To investigate whether plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) remains a specific marker of cardiac illness in very old age and can be used to identify very elderly people at high risk for death independent of the presence of known cardiac diagnoses.
Vaes, B., de Ruijter, W., Degryse, J.-M., Westendorp, R. G. J., & Gussekloo, J. (2009). Clinical relevance of a raised plasma N-terminal pro-brain natriuretic peptide level in a population-based cohort of nonagenarians. Journal of the American Geriatrics Society, 57(5), 823-829. https://doi.org/10.1111/j.1532-5415.2009.02218.x (Original work published 2009)