Fertility preservation in cancer patients : development of a transplantable artificial ovary prototype
(2017)
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- Authors
Chiti, Maria Costanza 
- Supervisors
- Abstract
- Ovarian tissue cryopreservation before gonadotoxic treatment is the only means of preserving fertility in prepubertal girls and women requiring prompt therapy. Despite growing success, with over 100 births to date, the safety of ovarian tissue grafting is of great concern in certain cancers, like leukemia, due to the potential risk of transferring malignant cells back to patients. Our laboratory is working on transplantation of isolated follicles and creation of an artificial ovary to offer these patients a safer alternative. In order to construct an artificial ovary prototype, a modified follicle isolation procedure was first developed to maximize the number and quality of isolated follicles for future clinical use. Human ovarian tissue was then analyzed to characterize its physical properties and duly recreate an artificial bio-environment in which follicles can be temporarily encapsulated before grafting.
- Affiliations
Citations
Chiti, M. C. (2017). Fertility preservation in cancer patients : development of a transplantable artificial ovary prototype. https://hdl.handle.net/2078.5/91186