Intramolecular cycloadditions with isobenzofurans .12. Synthesis and reactions of furo[3,4-d]isoxazoles

Reck, S;Bluhm, K;Debaerdemaeker, T.;Declercq, Jean-Paul;Friedrichsen, W;et.al.
(1996) Heterocycles — Vol. 43, n° 6, p. 1165-1170 (1996)

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  • Reck, S
    Author
  • Bluhm, K
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  • Debaerdemaeker, T.
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  • Declercq, Jean-PaulUCLouvain
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  • Friedrichsen, W
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Abstract
The synthesis of furo[3,4-d]isoxazoles (3) and inter- and intramolecular cycloaddition reactions (to 4, 5a,b) are reported. The structures of 3k, 5b and 6 have been clarified by X-ray crystallography. Quantum chemical calculations (AM1, PM3, ab initio, density functional methods) concerning the geometry and the different reactivity of benzo[c]furans and furo[3,4-d]isoxazoles were performed.
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Reck, S., Bluhm, K., Debaerdemaeker, T., Declercq, J.-P., Klenke, B., & Friedrichsen, W. (1996). Intramolecular cycloadditions with isobenzofurans .12. Synthesis and reactions of furo[3,4-d]isoxazoles. Heterocycles, 43(6), 1165-1170. https://doi.org/10.3987/COM-96-7434 (Original work published 1996)