Topical delivery by iontophoresis
(2001) Handbook of Cosmetic Science and Technology — ISBN: [978-1-57444-824-5], p. 211-219, published
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- Passive permeation of drugs across the skin is limited by the low permeability of thestratum corneum. Transdermal and topical delivery of drugs are presently applicable toonly a few drugs with appropriate balance hydro/lipophilicity, small size, no charge, andrelatively high potency [1,2].Strategies have been developed to increase transdermal and topical delivery acrossor into the skin. They consist of increasing the permeability of the skin or providing adriving force acting on the drug.Chemicals methods (e.g., penetration enhancers) or physi-cal methods (e.g., iontophoresis, sonophoresis, or electroporation) have been shown tosignificantly enhance transdermal transport [2–4].Iontophoresis is a noninvasive technique that uses a mild electric current to facilitatetransdermal delivery of drugs for both systemic and local effects. Iontophoretic transportof drugs has been extensively studied [5–8]. It has the potential to overcome many of thebarriers to topical drug absorption [6–13]. This chapter will focus on local delivery byiontophoresis as an aid to penetration of topically applied drugs. The mechanisms and theparameters affecting iontophoretic transport will be reviewed. The role of iontophoresisin clinical practice and cosmetics will be discussed
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Préat, V., & Vanbever, R. (2001). Topical delivery by iontophoresis. In Marc Paye, Andre O. Barel, Howard I. Maibach (ed.), Handbook of Cosmetic Science and Technology (p. p. 211-219). Taylor & Francis Group. https://hdl.handle.net/2078.5/240643