Lymphomas with kidney involvement: the French multicenter retrospective LyKID study.
(2020) Leukemia and Lymphoma — Vol. 61, n° 4, p. 887-895 (2020)
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Kohn, Milena 
- Abstract
- The LyKID study is a nationwide survey in France of lymphoma patients with renal involvement based on biopsy and/or imaging, to evaluate its impact on disease outcome and renal function. A total of 87 adult cases of B or T-cell lymphomas were retrospectively analyzed. Interstitial topography was observed in most of the kidney biopsies (54/66; 80%). Kidney failure (glomerular filtration rate <60 mL/min/1.73 m) was present in 47% of patients and was associated with non-significantly different outcome. After lymphoma treatment, 44% of patients had persistent chronic kidney failure (CKF); kidney failure at diagnosis was the only parameter associated with CKF in multivariate analysis. DLBCL (diffuse large B-cell lymphomas) represented half of the series, with noticeably CNS (central neurological system) relapse in 17% patients, while fewer than one of two patients had received CNS prophylaxis. To our knowledge, the LyKID study represents the largest published non-autopsy lymphoma series with renal involvement.
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Citations
Kohn, M., Karras, A., Zaidan, M., Bénière, C., de Fréminville, J.-B., Laribi, K., Perrin, M. C., Malphettes, M., Le Calloch, R., Anglaret, B., Martiniuc, J., Bailly, S., Chevret, S., Molina, T., Thervet, E., & Thieblemont, C. (2020). Lymphomas with kidney involvement: the French multicenter retrospective LyKID study. Leukemia and Lymphoma, 61(4), 887-895. https://doi.org/10.1080/10428194.2019.1697811 (Original work published 2020)