Diastereoselective 1,3-dipolar cycloadditions of new azomethine ylides derived from trifluorothioacetamides or cyanothioformamides

Laduron, Frédéric;Viehe, Heinz G.
(2002) Tetrahedron — Vol. 58, n° 18, p. 3543-3551 (2002)

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  • Laduron, FrédéricUCLouvain
    Author
  • Viehe, Heinz G.UCLouvain
    Author
Abstract
Deprotonation of trifluoromethyl or cyano thioamidium salts generates new azomethine ylides which undergo cycloaddition to dipolarophiles with high diastereoselectivity. Epimerisation, hydrolysis and reduction of the new trifluoromethylated heterocycles are also described. (C) 2002 Elsevier Science Ltd. All rights reserved.
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Laduron, F., & Viehe, H. G. (2002). Diastereoselective 1,3-dipolar cycloadditions of new azomethine ylides derived from trifluorothioacetamides or cyanothioformamides. Tetrahedron, 58(18), 3543-3551. https://doi.org/10.1016/S0040-4020(02)00308-3 (Original work published 2002)