Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects
(2015) The Journal of Pediatrics — Vol. 166, n° 1, p. 191-194 (2015)
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- (en) Congenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify these patients, and that elevated hormone levels may contribute to their pathophysiology.
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Shi, Y., Avatapalle, H. B., Skae, M. S., Padidela, R., Newbould, M., Rigby, L., Flanagan, S. E., Ellard, S., Rahier, J., Clayton, P. E., Dunne, M. J., Banerjee, I., & Cosgrove, K. E. (2015). Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects. The Journal of Pediatrics, 166(1), 191-194. https://doi.org/10.1016/j.jpeds.2014.09.019 (Original work published 2015)